Purpose: A series of 2-chloroquinoline containing pyrazoline derivatives having 3,4-dichloro/ 3,4-dimethoxy in the phenyl ring were. A series of new 2-pyrazoline derivatives has been synthesized by reacting 3-(substituted-phenyl)pyridinyl-propenones using two routes one using. The chalcone and pyrazoline derivatives were evaluated for their anti bacterial activity against Escherichia coli as gram negative and.
|Published:||28 December 2015|
|PDF File Size:||39.67 Mb|
|ePub File Size:||30.56 Mb|
For reproduction of material from all other RSC journals and books: If the material has pyrazoline derivatives adapted instead of reproduced from the original RSC publication "Reproduced from" can be substituted with "Adapted from".
Thin Layer Chromatography TLC was performed to check the purity of the compounds, the spot being located pyrazoline derivatives iodine vapors. General procedure for the synthesis of chalcones 1a-e, 2a-e 3,4-Dichloro acetophenone 1 or 3,4-dimethoxy acetophenone 2 0.
The reaction mixture was stirred overnight at room temperature. pyrazoline derivatives
Novel 2-Pyrazoline Derivatives as Potential Antibacterial and Antifungal Agents
Subsequently, this reaction mixture pyrazoline derivatives poured over crushed ice and neutralized to pH 7 with dilute HCl. The yellow solid thus obtained was filtered, washed with water, and dried.
The crude product was crystallized with a chloroform-ethanol mixture to afford pure chalcones. General pyrazoline derivatives for the synthesis of Pyrazolines 3a-e, 4a-e To a solution of chalcones 1a-e, 2a-e 0.
Journal of Chemistry
For reproduction of material from all other RSC journals and pyrazoline derivatives If the material has been adapted instead of reproduced from the original RSC publication "Reproduced from" can be substituted with "Adapted pyrazoline derivatives.
Synthesis of 1,3,5-trisubstitutedpyrazolines [compound P13 5- 4-fluorophenyl 4-fluorophenyl isonicotinoyl-pyrazoline ] 9 pyrazoline derivatives, 10 was performed by taking equimolar quantities 0.
The mixture was stirred over a magnetic stirrer for a period of 24 h and left in an ice chest overnight.
On the next day, the mixture was poured into a beaker containing ice-cold water. Then the aqueous layer was acidified with conc.